Description
Reactive oxygen species (ROS) play important roles in the initiation and progression of many disease processes. Most fluorescent probes for ROS detection, such as 2,7-dichlorofluorescein (DCFH), function by an oxidative mechanism and are useful for total oxidant detection but are not selective for hydrogen peroxide specifically.{12238} Pentafluorobenzenesulfonyl fluorescein is a fluorescent probe that functions by a nonoxidative mechanism. It fluoresces upon perhydrolysis of the sulfonyl linkage, and is selective for hydrogen peroxide over hydroxyl radical, tert-butyl hydroperoxide, superoxide anion, singlet oxygen, and nitrates. Pentafluorobenzenesulfonyl fluorescein can be used as a probe for hydrogen peroxide in whole cell systems.{12238}
Formal name: pentafluorobenzenesulfonic acid, 6’-hydroxy-3-oxospiro[isobenzofuran-1(3H),9’-[9H]xanthen]-3’-yl ester
Synonyms:
Molecular weight: 562.4
CAS: 728912-45-6
Purity: ≥98%
Formulation: A crystalline solid
Product Type|Biochemicals|Labeling & Detection|Fluorescent Probes||Research Area|Oxidative Stress & Reactive Species|Reactive Oxygen
