LPA is a potent lipid mediator that elicits its effect through four distinct receptors - LPA1/EDG-2

(2S)-OMPT – 5 mg

Brand:
Cayman
CAS:
1217471-69-6
Storage:
-20
UN-No:
De Minimis - 1992 / 3|6.1

Lysophosphatidic acid (LPA) is a potent lipid mediator that elicits its effect through four distinct receptors – LPA1/EDG-2, LPA2/EDG-4, LPA3/EDG-7 and LPA4/GPR23.{11049,13009} OMPT is a selective agonist of the lysophosphatidic acid 3 (LPA3) receptor. It exhibits EC50 values of 68 nM and >6.8 µM for calcium mobilization in LPA1 and LPA2-expressing Sf9 cells, respectively.{11057} The (2S)-OMPT enantiomer is 5- to 20-fold more active than (2R)-OMPT in calcium release assays in both LPA3-transfected Sf9 and rat hepatoma Rh7777 cells.{13369}  

 

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SKU: 10005707 - 5 mg Category:

Description

LPA is a potent lipid mediator that elicits its effect through four distinct receptors – LPA1/EDG-2, LPA2/EDG-4, LPA3/EDG-7 and LPA4/GPR23.{11049,13009} OMPT is a selective agonist of the LPA3 receptor. It exhibits EC50 values of 68 nM and >6.8 µM for calcium mobilization in LPA3 and LPA2-expressing Sf9 cells, respectively.{11057} The (2S)-OMPT enantiomer is 5- to 20-fold more active than (2R)-OMPT in calcium release assays in both LPA3-transfected Sf9 and rat hepatoma Rh7777 cells.{13369}

Formal name: 9Z-octadecenoic acid, (2S)-3-[(hydroxymercaptophosphinyl)oxy]-2-methoxypropyl ester, triethyl ammonium salt (1:2)

Synonyms: 

Molecular weight: 669

CAS: 1217471-69-6

Purity: ≥98%

Formulation: A solution in ethanol:chloroform (1:1)

Product Type|Biochemicals|Receptor Pharmacology|Agonists||Research Area|Lipid Biochemistry|Glycerophospholipids

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