An arachidonoyl amino acid; an activator of TRPV1 and TRPV4 (EC50s = 28 and 21 µM

N-Arachidonoyl Taurine – 1 mg

Brand:
Cayman
CAS:
119959-65-8
Storage:
-80
UN-No:
Non-Hazardous - /

N-Arachidonoyl taurine is an arachidonoyl amino acid.{16245} It is oxygenated by 12(S)- and 15(S)-lipoxygenase and is converted to 12-HETE-taurine (12-HETE-T) in murine resident peritoneal macrophages.{46067} N-Arachidonoyl taurine is an activator of the transient receptor potential vanilloid (TRPV) channels TRPV1 and TRPV4 (EC50s = 28 and 21 µM, respectively).{16245} It increases calcium flux in HIT-T15 pancreatic β-cells and INS-1 rat islet cells when used at a concentration of 10 µM and increases insulin secretion from 832/13 INS-1 pancreatic β-cells.{46068} The levels of N-arachidonoyl taurine are changed in mouse brain following administration of Δ9-tetrahydrocannabinol (Δ9-THC).{46069}  

 

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SKU: 10005537 - 1 mg Category:

Description

An arachidonoyl amino acid; an activator of TRPV1 and TRPV4 (EC50s = 28 and 21 µM, respectively); increases calcium flux in HIT-T15 pancreatic β-cells and INS-1 rat islet cells at 10 µM; increases insulin secretion from 832/13 INS-1 pancreatic β-cells; levels are changed in mouse brain following administration of Δ9-THC

Formal name: 2-[(1-oxo-5Z,8Z,11Z,14Z-eicosatetraenyl)amino]-ethane sulfonic acid

Synonyms: 

Molecular weight: 411.6

CAS: 119959-65-8

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Ion Channel Modulation|Activators||Product Type|Biochemicals|Lipids|Fatty Amides||Research Area|Lipid Biochemistry|Endocannabinoid/Endocannabinoid-like||Research Area|Neuroscience|Cannabinoid Research|Endocannabinoids

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