A lignan with diverse biological activities; reduces LPS-induced production of NO and PGE2 in RAW 264.7 cells; cytotoxic to colon 26 cancer cells (LC50 = 9 µg/ml); increases the lifespan of C. elegans at 100 µM; reduces oxaliplatin-induced neurotoxicity in neural PC12 cells at 0.4

Matairesinol – 25 mg

Brand:
Cayman
CAS:
580-72-3
Storage:
-20
UN-No:
Non-Hazardous - /

Matairesinol is a lignan that has been found in Forsythia and has diverse biological activities.{57103,57104,57105,57106,57107} It reduces LPS-induced production of nitric oxide (NO) and prostaglandin E2 (PGE2; Item No. 14010) in RAW 264.7 cells.{57103} Matairesinol is cytotoxic to colon 26 cancer cells (LC50 = 9 µg/ml).{57104} It increases the lifespan of C. elegans when used at a concentration of 100 µM.{57105} Matairesinol (0.4, 2, and 10 µM) reduces neurotoxicity in neural PC12 cells induced by oxaliplatin (Item No. 13106).{57106} Topical administration of matairesinol (50 µg/ear) reduces ear thickness and mast cell infiltration, as well as serum IgE levels, in a mouse model of dust mite-induced atopic dermatitis.{57107}  

 

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SKU: 10005174 - 25 mg Category:

Description

A lignan with diverse biological activities; reduces LPS-induced production of NO and PGE2 in RAW 264.7 cells; cytotoxic to colon 26 cancer cells (LC50 = 9 µg/ml); increases the lifespan of C. elegans at 100 µM; reduces oxaliplatin-induced neurotoxicity in neural PC12 cells at 0.4, 2, and 10 µM; topical administration reduces ear thickness and mast cell infiltration, as well as serum IgE levels, in a mouse model of dust mite-induced atopic dermatitis at 50 µg/ear

Formal name: dihydro-3R,4R-bis[(4-hydroxy-3-methoxyphenyl)methyl]-2(3H)-furanone

Synonyms:  (–)-Matairesinol

Molecular weight: 358.4

CAS: 580-72-3

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Natural Products|Lignans||Research Area|Cancer|Cell Death||Research Area|Cardiovascular System|Blood|Serum Proteins||Research Area|Cell Biology|Cell Signaling|Nitric Oxide Signaling||Research Area|Immunology & Inflammation|Adaptive Immunity||Research Area|Immunology & Inflammation|Inflammatory Lipid Mediators|Prostaglandins||Research Area|Immunology & Inflammation|Innate Immunity||Research Area|Neuroscience|Neuroprotection

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