A structural analog of 14(15)-EET that antagonizes EET-induced relaxation of vascular smooth muscle

14,15-EE-5(Z)-E – 25 µg

Brand:
Cayman
CAS:
519038-92-7
Storage:
-20
UN-No:
De Minimis - 1170 / 3

Epoxyeicosatrienoic acids (EETs), such as 11(12)-EET and 14(15)-EET, are cytochrome P450 metabolites of arachidonic acid that have been identified as endothelium-derived hyperpolarizing factors with vasodilator activity.{12391} 14,15-EE-5(Z)-E is a structural analog of 14,15-epoxyeicosatrienoic acids (14,15-EET) that antagonizes EET-induced relaxation of vascular smooth muscle.{14412} Relaxation of U46619-constricted bovine arteries by 14,15-EET could be inhibited approximately 80% by 14,15-EE-5(Z)-E at a concentration of 10 µM. 14,15-EE-5(Z)-E does not appear to antagonize nitric oxide- or iloprost-mediated vascular relaxation.  

 

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SKU: 10004946 - 25 µg Category:

Description

A structural analog of 14(15)-EET that antagonizes EET-induced relaxation of vascular smooth muscle

Formal name: 13-[(2R,3S)-3-pentyloxiranyl]-5Z-tridecenoic acid

Synonyms:  14,15-Epoxyeicosa-5(Z)-enoic Acid

Molecular weight: 324.5

CAS: 519038-92-7

Purity: ≥98%

Formulation: A solution in ethanol

Product Type|Biochemicals|Lipids|Hydroxy/Hydroperoxy/ Epoxy/Oxo Eicosanoids||Research Area|Cardiovascular System|Vasculature|Vasoconstriction||Research Area|Lipid Biochemistry|Cytochrome P450 Pathways

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