A cannabidiol (CBD) analog that acts as a selective antagonist of abnormal CBD (Abn-CBD) at the non-CB1/CB2 endothelial receptor; does not bind to CB1 or CB2 receptors at concentrations up to 30 µM and inhibits the vasorelaxant effects of Abn-CBD in vitro and in whole animals; blocks the Abn-CBD-induced activation of the PtdIns 3-kinase/Akt pathway in human umbilical vein endothelial cells

O-1918 – 25 mg

Brand:
Cayman
CAS:
536697-79-7
Storage:
-20
UN-No:
Excepted Quantity - 1231 / 3

Abnormal cannabidiol is a synthetic regioisomer of cannabidiol that fails to elicit either central cannabinoid (CB1) or peripheral cannabinoid (CB2) responsiveness and is without psychotropic activity. It induces endothelium-dependent vasodilation via a CB1/CB2/nitric oxide-independent mechanism. O-1918 is a cannabidiol analog that acts as a selective antagonist of abnormal cannabidiol at the non-CB1/CB2 endothelial receptor. It does not bind to CB1 or CB2 receptors at concentrations up to 30 µM and inhibits the vasorelaxant effects of abnormal cannabidiol in vitro and in whole animals.{11761} It also blocks the abnormal cannabidiol-induced activation of the phosphatidylinositol 3-kinase/Akt pathway in human umbilical vein endothelial cells.{11761}  

 

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SKU: 10004914 - 25 mg Category:

Description

A cannabidiol (CBD) analog that acts as a selective antagonist of abnormal CBD (Abn-CBD) at the non-CB1/CB2 endothelial receptor; does not bind to CB1 or CB2 receptors at concentrations up to 30 µM and inhibits the vasorelaxant effects of Abn-CBD in vitro and in whole animals; blocks the Abn-CBD-induced activation of the PtdIns 3-kinase/Akt pathway in human umbilical vein endothelial cells

Formal name: 1,3-dimethoxy-5-methyl-2-[(1R,6R)-3-methyl-6-(1-methylethenyl)-2-cyclohexen-1-yl]-benzene

Synonyms: 

Molecular weight: 286.4

CAS: 536697-79-7

Purity: ≥95%

Formulation: A solution in methyl acetate

Product Type|Biochemicals|Receptor Pharmacology||Research Area|Cardiovascular System|Vasculature|Vasoconstriction||Research Area|Neuroscience|Cannabinoid Research|CB1 & CB2 Receptors

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