A partial agonist of PPARγ; activates PPARγ with a lower potency (Ki = 15 versus 0.035 µM) but a similar maximal efficacy compared to rosiglitazone; improves insulin resistance in normal

FMOC-L-Leucine – 100 g

Brand:
Cayman
CAS:
35661-60-0
Storage:
22
UN-No:
Non-Hazardous - /

Peroxisome proliferator-activated receptor γ (PPARγ) isoforms heterodimerize with retinoic X receptors to modulate gene expression related to adipocyte differentiation, fatty acid uptake and storage, and glucose metabolis.{18294} Natural agonists of PPARγ include fatty acids (e.g., linoleic acid and 15-deoxy-Δ12,14-prostaglandin J2), while thiazolidinediones (e.g., rosiglitazone and pioglitazone) are potent synthetic agonists.{18295,18296} FMOC-L-leucine is a partial agonist of PPARγ.{11781,18295} It activates PPARγ with a lower potency (Ki = 15 versus 0.035 µM) but a similar maximal efficacy compared to rosiglitazone.{11781} FMOC-L-leucine improves insulin resistance in normal, diet-induced glucose-intolerant and in diabetic db/db mice, yet has reduced adipogenic activity.{11781} As a result, it is classified as a selective PPARγ modulator (SPPARM), capable of producing insulin-sensitizing effects while minimizing side effects associated with full agonists.{18295}  

 

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SKU: 10004888 - 100 g Category:

Description

A partial agonist of PPARγ; activates PPARγ with a lower potency (Ki = 15 versus 0.035 µM) but a similar maximal efficacy compared to rosiglitazone; improves insulin resistance in normal, diet-induced glucose-intolerant, and in diabetic db/db mice, yet reduced adipogenic activity

Formal name: N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-leucine

Synonyms:  FMOC-Leu|NPC 15199|NSC 334290

Molecular weight: 353.4

CAS: 35661-60-0

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Receptor Pharmacology|Agonists||Research Area|Endocrinology & Metabolism|Hormones & Receptors|PPARs||Research Area|Endocrinology & Metabolism|Metabolic Diseases|Diabetes

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