A non-selective inhibitor of both COX-1 and COX-2 with extensive epidemiology documenting its effective reduction of human colorectal cancer

Sulindac – 50 g

Brand:
Cayman
CAS:
38194-50-2
Storage:
-20
UN-No:
Limited Quantity - 2811 / 6.1

Many non-steroidal anti-inflammatory drugs (NSAIDs) are potent but non-selective inhibitors of both COX-1 and COX-2 in humans.{1286} Sulindac is one of the older NSAIDs, an isostere of indomethacin developed before the inducible form of COX-2 was discovered.{722} Although a number of NSAIDs have been found to protect against digestive tract cancers, sulindac has an extensive epidemiology documenting reduced human colorectal cancer. In murine models, sulindac was found not only to inhibit the enzymatic activity of polyp-associated COX-2, but also to downregulate the expression of colonic COX-2 protein to control levels.{4068}  

 

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SKU: 10004386 - 50 g Category:

Description

A non-selective inhibitor of both COX-1 and COX-2 with extensive epidemiology documenting its effective reduction of human colorectal cancer

Formal name: 5-fluoro-2-methyl-1Z-[[4-(methylsulfinyl)phenyl]methylene]-1H-indene-3-acetic acid

Synonyms: 

Molecular weight: 356.4

CAS: 38194-50-2

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors|Cyclooxygenases||Research Area|Cancer||Research Area|Immunology & Inflammation|Inflammatory Lipid Mediators|Prostaglandins||Research Area|Lipid Biochemistry|Cyclooxygenase Pathway

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