An agonist of GPR55 (EC50 = 2.5 µM in a GTPγS binding assay); selective for GPR55 over CB1 and CB2 (EC50s = >30 µM for both in GTPγS binding assays); a full agonist at GPR18 (EC50 = 0.835 µM for inducing p44/42 MAPK phosphorylation in HEK293 cells expressing GPR18); increases migration of BV-2 microglial cells (EC50 = 0.6 µM); decreases blood pressure in anesthetized rats at 20 µg/g

Abnormal Cannabidiol – 10 mg

Brand:
Cayman
CAS:
22972-55-0
Storage:
-20
UN-No:
De Minimis - 1231 / 3

Abnormal cannabidiol is a synthetic cannabidiol agonist of GPR55 (EC50 = 2.5 µM in a GTPγS binding assay).{17583} It is selective for GPR55 over cannabinoid (CB) receptor 1 (CB1) and CB2 (EC50s = >30 µM for both in GTPγS binding assays). It is also a full agonist at GPR18, with an EC50 value of 0.835 µM for inducing p44/42 MAPK phosphorylation in HEK293 cells expressing GPR18.{40399} Abnormal cannabidiol increases migration of BV-2 microglial cells (EC50 = 0.6 µM).{12500} It induces endothelium-dependent vasodilation via a CB1-CB2-NO-independent mechanism and inhibits vasoconstriction induced by endothelin 1 (ET-1; Item No. 24127) in retinal arterioles, an effect that can be blocked by the calcium-sensitive potassium channel blocker apamin (Item No. 17082).{11092,40401} Abnormal cannabidiol also decreases blood pressure in anesthetized rats when administered intravenously at a dose of 20 µg/g or when administered directly into the rostral ventrolateral medulla at 0.4 and 0.8 µg.{11092,40400}  

 

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SKU: 10004259 - 10 mg Category:

Description

An agonist of GPR55 (EC50 = 2.5 µM in a GTPγS binding assay); selective for GPR55 over CB1 and CB2 (EC50s = >30 µM for both in GTPγS binding assays); a full agonist at GPR18 (EC50 = 0.835 µM for inducing p44/42 MAPK phosphorylation in HEK293 cells expressing GPR18); increases migration of BV-2 microglial cells (EC50 = 0.6 µM); decreases blood pressure in anesthetized rats at 20 µg/g, i.v. or at 0.4 and 0.8 µg via rostral ventrolateral medulla injection

Formal name: 4-[(1R,6R)-3-methyl-6-(1-methylethenyl)-2-cyclohexen-1-yl]-5-pentyl-1,3-benzenediol

Synonyms:  Abn-CBD

Molecular weight: 314.5

CAS: 22972-55-0

Purity: ≥98%

Formulation: A solution in methyl acetate

Product Type|Biochemicals|Receptor Pharmacology|Agonists||Research Area|Cardiovascular System|Vasculature|Vasodilation||Research Area|Neuroscience|Cannabinoid Research|CB1 & CB2 Receptors

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