A biologically active peroxidation product of linoleic acid; activates an ARE in neuronal cells and induces the expression of ARE-regulated cytoprotective genes; also stimulates the synthesis of aldosterone and corticosterone in adrenal cells when supplied at 1-5 μM

trans-EKODE-(E)-Ib – 50 µg

Brand:
Cayman
CAS:
478931-82-7
Storage:
-20
UN-No:
De Minimis - 1170 / 3

During oxidative stress, the abundant unsaturated fatty acid linoleic acid undergoes lipid peroxidation to produce α,β-unsaturated epoxy-keto-octadecenoic acids (EKODEs). Nonenzymatic autooxidation of linoleic acid generates six major EKODE isomers, which differ from one another in the positioning and the orientation of the epoxy group relative to the keto moiety. trans-EKODE-(E)-Ib is a biologically active peroxidation product of linoleic acid that is characterized, structurally, by having a trans carbon-carbon double bond between the 9-keto and 12,13-epoxy groups. It activates an antioxidant response element (ARE) in neuronal cells and induces the expression of ARE-regulated cytoprotective genes like NQO1.{17702} This EKODE also stimulates the synthesis of aldosterone and corticosterone in adrenal cells when supplied at 1-5 μM.{17699,17700} This effect appears to be mediated by a rise in intracellular calcium.{17701}  

 

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SKU: 10004224 - 50 µg Category:

Description

A biologically active peroxidation product of linoleic acid; activates an ARE in neuronal cells and induces the expression of ARE-regulated cytoprotective genes; also stimulates the synthesis of aldosterone and corticosterone in adrenal cells when supplied at 1-5 μM

Formal name: 9-oxo-11-(3-pentyl-2-oxiranyl)-10E-undecenoic acid

Synonyms:  12,13-epoxy-9-keto-10(trans)-Octadecenoic Acid

Molecular weight: 310.4

CAS: 478931-82-7

Purity: ≥98%

Formulation: A solution in ethanol

Product Type|Biochemicals|Lipids|Octadecanoids||Product Type|Biochemicals|Ox Stress Reagents|Antioxidants||Research Area|Lipid Biochemistry|Reactive O2/N2 Pathways||Research Area|Oxidative Stress & Reactive Species|Lipid Peroxidation

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