Promotes the cytochrome c-dependent oligomerization of Apaf-1 into the mature apoptosome

Apoptosis Activator 2 – 25 mg

Brand:
Cayman
CAS:
79183-19-0
Storage:
-20
UN-No:
Non-Hazardous - /

Apoptosis activator 2 promotes the cytochrome c-dependent oligomerization of Apaf-1 into the mature apoptosome, thus increasing procaspase-9 processing and subsequent caspase-3 activation.{11535} This compound has been shown to induce apoptosis in leukemia cells (IC50 = 4-9 μM) with weak or no effect on normal cell lines or those lacking Apaf-1, caspase-9, or caspase-3 activity (IC50s > 40 μM).{11535}  

 

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SKU: 10004176 - 25 mg Category:

Description

Promotes the cytochrome c-dependent oligomerization of Apaf-1 into the mature apoptosome, thus increasing procaspase-9 processing and subsequent caspase-3 activation; induces apoptosis in leukemia cells (IC50 = 4-9 μM)

Formal name: 1-[(3,4-dichlorophenyl)methyl]-1H-indole-2,3-dione

Synonyms:  AAII|N-(3,4-dichlorobenzyl) Isatin

Molecular weight: 306.1

CAS: 79183-19-0

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Activators|Caspases||Research Area|Cancer|Cell Death|Apoptosis||Research Area|Cell Biology|Proteolysis|Cytosolic & Secreted Proteases

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