4-ONE-d3 contains three deuterium atoms at the terminal methyl position. It is intended for use as an internal standard for the quantification of 4-ONE by GC- or LC-MS.

4-oxo-2-Nonenal-d3 – 50 µg

Brand:
Cayman
CAS:
1313400-91-7
Storage:
-80
UN-No:
De Minimis - 1231 / 3

4-oxo-2-Nonenal-d3 (4-ONE-d3) contains three deuterium atoms at the terminal methyl position. It is intended for use as an internal standard for the quantification of 4-ONE (Item No. 10185) by GC- or LC-mass spectrometry (MS). 4-ONE is a lipid peroxidation product derived from oxidized ω-6 polyunsaturated fatty acids such as arachidonic acid and linoleic acid.{869,1103} It exhibits various biological activities such as cytotoxicity, growth inhibiting activity, genotoxicity, and chemotactic activity and has been widely used as a marker of lipid peroxidation.{869,1103,1109} 4-ONE is a more recently identified product of lipid peroxidation.{9278,11422,11421} It actively modifies histidine and lysine residues on proteins and causes protein cross-linking.{11420,11419} 4-ONE also modifies 2′-deoxy guanosine, further implicating lipid peroxidation in mutagenesis and carcinogenesis.{869}  

 

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SKU: 10004174 - 50 µg Category:

Description

4-ONE-d3 contains three deuterium atoms at the terminal methyl position. It is intended for use as an internal standard for the quantification of 4-ONE by GC- or LC-MS.

Formal name: 4-oxo-2E-nonenal-d3

Synonyms:  4-ONE-d3

Molecular weight: 157.2

CAS: 1313400-91-7

Purity: ≥99% deuterated forms (d1-d3)

Formulation: A solution in methyl acetate

Application|Mass Spectrometry||Product Type|Biochemicals|Analytical Standards||Product Type|Biochemicals|Isotopically Labeled Standards|Deuterium||Product Type|Biochemicals|Lipids|Fatty Alcohols/Aldehydes||Research Area|Lipid Biochemistry|Reactive O2/N2 Pathways||Research Area|Oxidative Stress & Reactive Species|Lipid Peroxidation

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