Leptomycin B – 5 µg

Brand:
Cayman
CAS:
87081-35-4
Storage:
-20
UN-No:
De Minimis - 1170 / 3

Leptomycin B is a potent inhibitor of the nuclear export of proteins. It directly blocks the interaction of CRM1 (exportin 1) with nuclear export signals (NES), preventing the export of a broad range of proteins.{15319} Leptomycin B will also indirectly inhibit the export of mRNA from the nucleus by blocking the nuclear export of mRNA-binding proteins (export factors).{15320} By blocking the nuclear export of p53, leptomycin B prevents entry of human normal fibroblasts into the S phase of the cell cycle, thus inhibiting proliferation.{15382} Leptomycin B was originally identified as an antifungal agent and is isolated from Streptomyces sp..  

 

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Description

A potent anti-fungal antibiotic that can directly block nuclear transport by inhibiting the action of CRM1


Formal name: 19-[(2S,3S)-3,6-dihydro-3-methyl-6-oxo-2H-pyran-2-yl]-17-ethyl-6-hydroxy-3,5S,7S,9R,11,15R,hexamethyl-8-oxo-2E,10E,12E,16Z,18E-nonadecapentaenoic acid

Synonyms:  Elactocin|LMB|Mantuamycin|NSC 364372

Molecular weight: 540.7

CAS: 87081-35-4

Purity: ≥98%

Formulation: A solution in ethanol


Product Type|Biochemicals|Antifungals||Product Type|Biochemicals|Natural Products|Microbial Metabolites||Product Type|Biochemicals|Small Molecule Inhibitors||Research Area|Cell Biology|Cell Cycle