An inhibitor of Akt1 translocation that also inhibits hepatitis C virus (HCV) NS5B RNA-dependent RNA polymerase (RdRp) (IC50 = 79 µM)

CAY10567 – 500 mg

Brand:
Cayman
CAS:
32387-96-5
Storage:
-20
UN-No:
Non-Hazardous - /

Akt1, 2, and 3 are serine/threonine protein kinases in the phosphatidylinositol 3 (PI3)-kinase signalling pathway that play a critical role in the regulation of cell proliferation and survival.{12235,13740} Following recruitment of Akt to the plasma membrane, phosphorylation at threonine 308 and serine 473 (Akt1 numbering) by phosphoinositide-dependent kinases (PDK) 1 and 2 results in full activation of the enzyme. CAY10567 is an Akt1 translocation inhibitor. At a concentration of 12.5 µM, it prevents the translocation of Akt1 by apparently compromising the function of the PH domain. A structurally similar compound inhibits kinase activity in vitro with an EC50 value of 12 µM by binding to the kinase domain.{15664} CAY10567 also inhibits hepatitis C virus (HCV) NS5B RNA-dependent RNA polymerase (RdRp) with an IC50 value of 79 µM. {15663}  

 

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Description

An inhibitor of Akt1 translocation that also inhibits hepatitis C virus (HCV) NS5B RNA-dependent RNA polymerase (RdRp) (IC50 = 79 µM)

Formal name: 2,3-diphenyl-6-quinoxalinecarboxylic acid

Synonyms:  BML-257

Molecular weight: 326.4

CAS: 32387-96-5

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Antivirals|DNA & RNA Polymerase Inhibitors||Product Type|Biochemicals|Small Molecule Inhibitors|Nucleic Acid Turnover/Signaling||Research Area|Cell Biology|Cell Signaling|PI3K/Akt/mTOR Signaling||Research Area|Infectious Disease|Viral Diseases|Hepatitis

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