Description
Histone H3 is a nuclear protein and a component of the nucleosome core, a basic unit of chromatin, that is essential for organizing genomic DNA in eukaryotic nuclei.{57056} It is a globular protein that contains an unstructured N-terminal tail that extends outside of the nucleosome core and is subject to various post-translational modifications (PTMs), including methylation, phosphorylation, acetylation, and citrullination.{57056,53978} Trimethylation of histone H3 at lysine 79 (H3K79Me3) is found at promoter regions of both active and silenced genes in human CD4+ T cells and positively correlates with transcriptional repression.{46241} H3K79Me3 is also found at pericentromeric heterochromatin in mouse oocytes and somatic cells.{46242} Levels of H3K79Me3 are decreased in human tumor tissue compared to non-cancerous tissue.{46243} Cayman’s Histone H3K79Me3 Monoclonal Antibody can be used for ELISA, multiplex-based assays, and Western blot (WB) applications.
Synonyms: Trimethylated Histone H3 Lysine 79
Immunogen: A peptide corresponding to H3K79Me3
Formulation: 100 µg of protein A-affinity purified monoclonal antibody
Isotype: IgG
Applications: ELISA, multiplex-based assays, WB
Origin:
Stability: 365 days
Application|ELISA||Application|Multiplex||Application|Western Blot||Product Type|Antibodies|Monoclonal Antibodies||Research Area|Epigenetics, Transcription, & Translation|Erasers|Histone Demethylation||Research Area|Epigenetics, Transcription, & Translation|Histones/Histone Peptides|Methylated||Research Area|Epigenetics, Transcription, & Translation|Writers|Histone Methylation||Research Area|Immunology & Inflammation|Adaptive Immunity
