Description
Protein arginine deiminase 3 (PAD3; Item No. 10786) is a homodimeric guanidine-modifying enzyme belonging to the amidinotransferase superfamily.{34555} It is a calcium-dependent enzyme that catalyzes the post-translational modification of target proteins by converting arginine to citrulline. Substrates of PAD3 include filaggrin, trichohyalin, apoptosis-inducing factor (AIF), vimentin, and other proteins.{34556} PAD3 is expressed in the epidermis, hair follicles, and keratinocytes. It has a role in shaping and mechanical strengthening of hair, and mutations in PAD3 lead to uncombable hair syndrome.{36391} PAD3 is also expressed in mammary glands and citrullinates proteins during lactation.{34764} Cayman’s PAD3 Monoclonal Antibody (Clone 4E5) can be used for Western blot and ELISA. The predicted size for PAD3 is 76.4 kDa and Cayman’s PAD3 Monoclonal Antibody (Clone 4E5) recognizes PAD3 at ~74 kDa from human samples.
Synonyms: PADI3|PDI3|Peptidylarginine Deiminase 3|Protein Arginine Deiminase 3
Immunogen: Full length recombinant PAD3 protein
Formulation: 100 µg of Protein G-purified antibody
Isotype: IgG1
Applications: ELISA and WB
Origin:
Stability: 365 days
Application|ELISA||Application|Western Blot||Product Type|Antibodies|Monoclonal Antibodies||Research Area|Endocrinology & Metabolism|Reproductive Biology||Research Area|Epigenetics, Transcription, & Translation|Writers|Citrullination
