Description
The enzyme 5-lipoxygenase (5-LO) plays a key role in regulating the production of leukotrienes (LTs).{12243} Overproduction of LTs contributes to several diseases, most notably chronic inflammatory diseases such as asthma, fibrosis,{956} and atherosclerosis. Recent work has demonstrated that the activity of 5-LO is regulated by protein kinase A (PKA) phosphorylation of serine-523 in 5-LO. Under normal conditions, this phosphorylation may be important in limiting inflammation. Abnormal signaling through cAMP and PKA, may therefore contribute to a variety of diseases, including those characterized by chronic inflammation. The phospho-specific antibody to Ser523 on 5-LO provides a valuable tool for studying the role of 5-LO regulation in diseases such as asthma, fibrosis, and atherosclerosis.
Synonyms: 5-LO (Phospho-Ser523) Polyclonal Antibody
Immunogen: phosphopeptide corresponding to amino acid residues surrounding phospho-Ser523 of human 5-lipoxygenase (5-LO)
Formulation: Affinity-purified rabbit polyclonal antibody
Isotype:
Applications: WB
Origin: Animal/Rabbit
Stability: 365 days
Application|Western Blot||Product Type|Antibodies|Polyclonal Antibodies||Research Area|Cardiovascular System|Cardiovascular Diseases|Atherosclerosis||Research Area|Immunology & Inflammation|Inflammatory Lipid Mediators|Leukotrienes||Research Area|Immunology & Inflammation|Pulmonary Diseases|Asthma||Research Area|Lipid Biochemistry|Lipoxygenase Pathways
