Description
Triglycerides are the most efficient form of energy storage in mammalian adipose tissue during times of caloric excess. ATGL is one of the key enzymes involved in the mobilization of fatty acids from triglyceride stores in adipose tissue, catalyzing the conversion of triacylglycerols to diacylglycerols.{12373} Inhibition of ATGL markedly decreases total adipose acyl-hydrolase activity, and thus may be a potential drug target for the diabetic pathology.{12373} ATGL mRNA is detected in a wide range of tissues including adipose, lung, skeletal muscle, testis, heart, brain, and kidney, with adipose tissue expressing the highest level.{13488} Human ATGL is 504 amino acids in length with an estimated molecular weight of 55.2 kDa. Cayman’s ATGL Polyclonal Antibody detects the enzyme at 56 kDa by Western blot from tissues and cells such as brown fat, liver, mouse macrophages, and HepG2 cells.
Synonyms: ATGL|Calcium-independent Phospholipase A2|Desnutrin|IPLA2-ζ|Patatin-like Phospholipase Domain-containing Protein 2|Phospholipase A2ζ|Pigment Epithelium-derived Factor|PNPLA2|TTS2.2
Immunogen: Synthetic peptide from an internal region of human ATGL
Formulation: 500 μl of peptide affinity-purified antibody
Isotype:
Applications: IHC (paraffin-embedded tissue) and WB
Origin: Animal/Rabbit
Stability: 365 days
Application|Immunohistochemistry||Application|Western Blot||Product Type|Antibodies|Polyclonal Antibodies||Research Area|Cardiovascular System|Heart||Research Area|Endocrinology & Metabolism|Metabolic Diseases|Diabetes||Research Area|Endocrinology & Metabolism|Metabolic Diseases|Dyslipidemias
